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Premier Control Technologies Fluid Solutions

Biotechnology

Biotechnology Industry Solutions

Biotechnology is at the forefront of innovation in pharmaceuticals, diagnostics, and industrial processes. From upstream cell culture to downstream purification and final fill, every stage demands precision, sterility, and compliance. Accurate control of gases, liquids, and utilities ensures product quality, regulatory adherence, and process efficiency.

At Premier Control Technologies, we provide validated solutions for gas and liquid handling, clean steam systems, and critical utilities. Our portfolio includes mass flow controllers, sanitary valves, peristaltic pumps, and advanced instrumentation, all designed to meet GMP, ASME BPE, and USP Class VI standards.

Typical biotech applications

Bioreactor Gas Control

Bioreactors require precise control of O₂, CO₂, N₂, and air to maintain optimal cell growth conditions. Gas flow must be accurate and responsive to changing metabolic demands. Poor control can lead to reduced yields and contamination risks.

Relevant products:

  • Alicat BIO Series Mass Flow Controllers – Designed for bioprocessing, offering a 10,000:1 turndown ratio to eliminate multiple gas lines. Built with 316L stainless steel and USP Class VI elastomers for hygienic compliance.
    Key benefits:
    • Digital protocols for Pharma 4.0 integration
    • Resistant to water ingress for reliability
  • CODA Coriolis Mass Flow Meters – Provide direct mass measurement for gases and liquids, unaffected by pressure or temperature changes.
    Key benefits:
    • High accuracy for nutrient feeds and sparging
    • Compact design for skid integration
    • Ideal for solvent and additive dosing
Oenologists working in a laboratory

Media & Buffer Preparation

Accurate preparation of media and buffers is critical for cell culture and downstream processing. This involves precise dosing of liquids and powders, often under sterile conditions.

Relevant products:

  • Peristaltic Pumps (Longer dPOFLEX) – Enable contamination-free transfer using single-use tubing.
  • Key benefits:
    • Low pulsation for accurate dosing
    • 21 CFR Part 11 compliance
    • Low pulsation for accurate dosing
    • Quick tubing changeover for reduced downtime
  • Steriflow Sanitary Control Valves (Mark 978JD) - Provide precise flow control for buffer addition and mixing.
  • Key benefits:
    • ASME BPE-compliant design
    • Electropolished surfaces for hygiene
    • Full CIP/SIP capability

Aseptic Filling & Dosing

Final fill operations require ultra-precise dosing and sterile conditions to ensure product integrity.

Relevant products:

  • Micro-gear and Valveless Piston Pumps – Deliver accurate micro-dosing for high-value biologics.
  • Key benefits:
    • High repeatability for critical fills
    • Compact design for isolators and RABS
    • Compatible with single-use systems

Fermentation Pressure Control

Fermenters must maintain stable pressure to optimize microbial growth and prevent contamination.

Relevant products:

Clean Steam & CIP/SIP Systems

Clean steam and CIP/SIP systems are essential for sterilization and cleaning in biotech facilities.

Relevant products:

  • Steriflow SSRV Safety Relief Valves – Protect systems from overpressure during sterilization cycles.
  • Key benefits:
    • ASME BPE finishes
    • Full CIP/SIP compatibility
    • Reliable overpressure protection

Chromatography & Filtration Skids

Downstream purification requires precise flow and pressure control for chromatography columns and filtration systems.

Relevant products:

  • Alicat Pressure Controllers – Automate pressure control for filtration and chromatography skids.
  • Key benefits:
    • Fast response for process stability
    • Digital integration for automation
    • Compact footprint for skid design

Single-Use Systems & Tubing

Single-use technology reduces cleaning validation and contamination risk in biotech processes.

Relevant products:

Lyophilisation (Freeze Drying)

Freeze drying stabilizes sensitive biologics by removing water under vacuum.

Relevant products:

  • Pressure Transmitters – Monitor chamber pressure during sublimation.
  • Key benefits:
    • High accuracy for critical control
    • Hygienic design for sterile environments
    • Easy integration with automation

Packaging & Integrity Testing

Packaging integrity ensures sterility and shelf life for biotech products.

Relevant products:

  • Mass Flow Controllers – Provide precise flow for vacuum decay or pressure hold tests.
  • Key benefits:
    • Reliable detection of micro-leaks
    • Reduces risk of product recalls

Biotechnology Application Selection Guide

ApplicationRecommended TechnologiesWhy It Helps
Bioreactor Gas ControlAlicat BIO Series, CODA CoriolisWide turndown, CIP/SIP, Pharma 4.0 ready
Media & Buffer PrepPeristaltic Pumps, Steriflow ValvesAccurate dosing, hygienic design
Aseptic FillingMicro-gear & Valveless PumpsHigh precision, single-use compatibility
Fermentation PressureSteriflow RegulatorsStable pressure, hygienic compliance
Clean Steam & CIP/SIPSteriflow SSRV & RegulatorsOverpressure protection, ASME BPE
Chromatography & FiltrationAlicat Pressure ControllersAutomated pressure control
Single-Use SystemsPeristaltic Tubing & AssembliesReduced cleaning validation
Environmental MonitoringHumidity & Dew Point SensorsContinuous GMP compliance
LyophilisationPressure TransmittersAccurate vacuum control
Packaging IntegrityMFCs & Pressure ControllersReliable leak detection

FAQs

Yes, Steriflow valves and Alicat BIO controllers meet ASME BPE and USP Class VI standards.
Yes, our peristaltic pumps and tubing assemblies are designed for single-use applications.
Yes, Alicat controllers support Modbus, Profibus, and Ethernet/IP.
Yes, Steriflow sanitary valves are fully CIP/SIP capable.
Yes, we provide humidity, dew point, temperature, and pressure sensors for cleanrooms and utilities.
Yes, our peristaltic and valveless piston pumps can handle a wide range of viscosities.
Yes, our team offers full application support and integration guidance.

Helpful resources

Customers purchase these products

Alicat M Series Mass Flow Meter - Colour screen Alicat M Series Meter - Standard Model Alicat MS Series - Specialised Anti Corrosive Gas Mass Flow Meter Alicat MS Series Meter - Anti Corrosive Alicat MB Series of Portable Gas Mass Flow Meters Alicat MB Series Meter - Portable Alicat MC - Gas Mass Flow Controller Alicat MC Series Controller - Standard Controller Alicat MCS - Anti Corrosive Gas Mass Flow Controller Alicat MCS Series Controller - Anti Corrosive Alicat PC3 PCR3 - Single Valve Pressure Controller Alicat PC3 PCR3 - Single Valve Pressure Controller Alicat PCR - Single Valve Pressure Controller - Differential control Alicat PCR - Single Valve Pressure Controller Alicat PC - Pressure Controller Alicat PC - Pressure Controller Alicat Basis 2.0 - OEM Gas Mass Flow Controller Alicat Basis 2.0 Series Controller - OEM Applications Supercritical BR Series Back pressure regulator Supercritical BR Series Alicat MQ Series - The High Pressure Gas Mass Flow Meter Alicat MQ Series Meter - High Pressure Alicat MCQ - High Pressure Gas Mass Flow Controller Alicat MCQ Series Controller - High Pressure Alicat BIO - Gas Mass Flow Controller for Bioprocessing Alicat BIO Series Controller - Bioprocessing Biopharmaceutical SD Series back pressure regulator Biopharmaceutical SD Series Alicat CODA Coriolis High Accuracy Flow Meter Alicat CODA Coriolis High Accuracy Flow Meter Alicat CODA Coriolis High Accuracy Flow Controller Alicat CODA Coriolis High Accuracy Flow Controller Alicat CODA Coriolis Standard Accuracy Flow Meter Alicat CODA Coriolis Standard Accuracy Flow Meter Alicat CODA Coriolis Standard Accuracy Flow Controller Alicat CODA Coriolis Standard Accuracy Flow Controller Mark 96 Series Sanitary Pressure Regulator Steriflow Mark 96 Series Sanitary Pressure Regulator Mark 96A Series Sanitary Air Loaded Pressure Regulator Steriflow Mark 96A Series Sanitary Air Loaded Pressure Regulator Mark 96AA Series Sanitary Air Augmented Pressure Regulator Steriflow Mark 96AA Series Sanitary Air Augmented Pressure Regulator JSRH Series High Flow Bio-Pharma Clean Gas Pressure Reducing Valve Steriflow JSRH JSRHF Series High Flow Bio-Pharma Clean Gas Pressure Reducing Valves JSRLFLP Series Low Flow Bio-Pharma Clean Gas Pressure Reducing Valve Steriflow JSRLFLP Series Low Flow Bio-Pharma Clean Gas Pressure Reducing Valves Mark 95FT Series Sanitary Back Pressure Regulator Steriflow Mark 95FT Series Sanitary Back Pressure Regulator JSB Series High Purity Back Pressure Regulating Valve Steriflow JSB Series High Purity Back Pressure Regulating Valve Mark 978JD Series Sanitary Control Valve Steriflow Mark 978JD Series Sanitary Control Valve Mark 978OR Series Sanitary Control Valve Steriflow Mark 978OR Series Sanitary Control Valve Mark 978LF Series Sanitary Low Flow Control Valve Steriflow Mark 978LF Series Sanitary Low Flow Control Valve Mark 908 Series Low Pressure Blanketing Pressure Reducing Valve Steriflow Mark 908 Series Low Pressure Blanketing Pressure Reducing Valve JSRLFULP Series Pressure Reducing Valve Steriflow JSRLFULP Series Pressure Reducing Valve JSRHULP Series High Flow Pressure Reducing Valve Steriflow JSRHULP Series High Flow Pressure Reducing Valve Mark 94 Series High Flow Sanitary Steam Traps Steriflow Mark 94 Series High Flow Sanitary Steam Traps SSC Series Sub-cooled Condensers Steriflow SSC Series Sub-cooled Condensers Longer dPOFLEX Biopharmaceutical Peristaltic Pump - 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Front view Metering Pump Duplex Precision Mixing Pump Front view Duplex Precision Mixing Pump FMI RHV Series Low Flow Variable Speed Pump FMI RHV Series Low Flow Variable Speed Pump FMI RHB Series Direct Current Pump FMI RHB Series Direct Current Pump FMI QBLDC20 Series Direct Current Pump FMI QBLDC20 Series Direct Current Pump FMI QBLDC55 Series Direct Current Pump FMI QBLDC55 Series Direct Current Pump FMI QBLDC150 Series Direct Current Pump FMI QBLDC150 Series Direct Current Pump FMI QBLDC250 Series Direct Current Pump FMI QBLDC250 Series Direct Current Pump FMI QBLDC400 Series Direct Current Pump FMI QBLDC400 Series Direct Current Pump FMI QBLDC500 Series Direct Current Pump FMI QBLDC500 Series Direct Current Pump FMI QBLDC1550 Series Direct Current Pump FMI QBLDC1550 Series Direct Current Pump FMI RH Series Miniature Motorless Pump Head FMI RH Series Miniature Motorless Pump Head FMI Q1 Series Pump Head FMI Q1 Series Pump Head FMI Q2 Series Pump Head FMI Q2 Series Pump Head FMI Q3 Series Pump Head FMI Q3 Series Pump Head FMI Q0 Series Pump Head FMI Q0 Series Pump Head FMI SPD Series OEM Pump Drive FMI SPD Series FMI GPD Series Pump Drive module FMI GPD Series FMI QB Series Direct Current Pump FMI QB Series Direct Current Pump FMI QD Series High Speed High Flow Pump FMI QD Series High Speed High Flow Pump FMI QV Series Variable Speed Pump FMI QV Series Variable Speed Pump FMI QBLDC Series Direct Current Pump FMI QBLDC Series Direct Current Pump TRYTON™ Pulseless Nanoliter Dispensing Pump TRYTON™ Pulseless Nanoliter Dispensing Pump Longer ASP100 Series Syringe Pump Longer ASP100 Series Syringe Pump Longer LSP10-1B Series 10-Channel Syringe Pump Longer LSP10-1B Series 10-Channel Syringe Pump Longer FU4B Peristaltic Filling System Longer FU4B Peristaltic Filling System GM200 mini peristaltic pump with yz1515x pump head Longer GM200-2B / GM400-2B Mini Peristaltic Pump Bag 2D Single-Use Bioprocessing Bags Bag 2D Single-Use Bioprocessing Bags FENYX+™ Variable Dispense Pump - 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